RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

Insulin-like growth factor-I (IGF-I) provides pivotal cell survival and differentiation signals during inner ear development throughout evolution. Homozygous mutations of human IGF1 cause syndromic sensorineural deafness, decreased intrauterine and postnatal growth rates, and mental retardation. In...

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Bibliographic Details
Main Authors: Hortensia Sanchez-Calderon, Lourdes Rodriguez-de la Rosa, Marta Milo, Jose G Pichel, Matthew Holley, Isabel Varela-Nieto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2810322?pdf=render

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http://europepmc.org/articles/PMC2810322?pdf=render

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