Parthenolide Sensitizes Human Colorectal Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand through Mitochondrial and Caspase Dependent Pathway

Parthenolide Sensitizes Human Colorectal Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand through Mitochondrial and Caspase Dependent Pathway

Background/AimsCombination therapy utilizing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in conjunction with other anticancer agents, is a promising strategy to overcome TRAIL resistance in malignant cells. Recently, parthenolide (PT) has proved to be a promising anticancer...

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Bibliographic Details
Main Authors: Kieu Thi Thu Trang, Se-Lim Kim, Sang-Bae Park, Seung-Young Seo, Chung-Hwan Choi, Jin-Kyoung Park, Jin-Chang Moon, Soo-Teik Lee, Sang-Wook Kim
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2014-01-01
Series:Intestinal Research
Subjects:
Parthenolide
TRAIL
Colorectal neoplasm
TRAIL resistance
Apoptosis
Online Access:http://www.irjournal.org/upload/pdf/ir-12-34.pdf

Internet

http://www.irjournal.org/upload/pdf/ir-12-34.pdf

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