Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Gastric cancer (GC) is characterized by poor efficacy and modest clinical impact of current therapies, in which apoptosis evasion is relevant. Intracellular calcium homeostasis dysregulation is associated with apoptosis escaping, and aberrant expression of calcium regulator genes could promote GC dr...

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Bibliographic Details
Main Authors: Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
drug resistance
gastric cancer
TRPV2
calcium channels
target therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.746628/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.746628/full

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