A novel peptide defined through phage display for therapeutic protein and vector neuronal targeting

A novel peptide with the binding characteristics of tetanus toxin was identified with phage display, for application in therapeutic protein and vector motor and sensory neuron targeting. A 12mer phage library was biopanned on trisialoganglioside (GT1b) and eluted with the tetanus toxin C fragment (r...

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Bibliographic Details
Main Authors: James K. Liu, Qingshan Teng, Mary Garrity-Moses, Thais Federici, Diana Tanase, Michael J. Imperiale, Nicholas M. Boulis
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610500032X