Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases. Developmentally, interneurons migrate from a distal progenitor domain in order to populate the neocortex – a process that occurs at a...

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Bibliographic Details
Main Authors: Matthieu Genestine, Daisy Ambriz, Gregg W Crabtree, Patrick Dummer, Anna Molotkova, Michael Quintero, Angeliki Mela, Saptarshi Biswas, Huijuan Feng, Chaolin Zhang, Peter Canoll, Gunnar Hargus, Dritan Agalliu, Joseph A Gogos, Edmund Au
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
brain development
interneuron
neovascularization
Online Access:https://elifesciences.org/articles/56063

Internet

https://elifesciences.org/articles/56063

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