Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity

PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARγ action on insulin sensitivity. PPARγ activation in mature adipocytes induces...

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Bibliographic Details
Main Authors: Anna Leonardini, Luigi Laviola, Sebastio Perrini, Annalisa Natalicchio, Francesco Giorgino
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2009/818945