Single-molecule visualization of fast polymerase turnover in the bacterial replisome

Single-molecule visualization of fast polymerase turnover in the bacterial replisome

The Escherichia coli DNA replication machinery has been used as a road map to uncover design rules that enable DNA duplication with high efficiency and fidelity. Although the enzymatic activities of the replicative DNA Pol III are well understood, its dynamics within the replisome are not. Here, we...

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Bibliographic Details
Main Authors: Jacob S Lewis, Lisanne M Spenkelink, Slobodan Jergic, Elizabeth A Wood, Enrico Monachino, Nicholas P Horan, Karl E Duderstadt, Michael M Cox, Andrew Robinson, Nicholas E Dixon, Antoine M van Oijen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
DNA replication
DNA polymerase
single-molecule
multiprotein complexes
fluorescence microscopy
Online Access:https://elifesciences.org/articles/23932

Internet

https://elifesciences.org/articles/23932

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