The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor

The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor

1,2-naphthoquinone (1,2-NQ) and 1,4-naphthoquinone (1,4-NQ) are clinically promising biologically active chemicals that have been shown to stimulate the aryl hydrocarbon receptor (AhR) signaling pathway, but whether they are direct or indirect ligands or activate the AhR in a ligand-independent mann...

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Bibliographic Details
Main Authors: Samantha C. Faber, Sara Giani Tagliabue, Laura Bonati, Michael S. Denison
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
aryl hydrocarbon receptor
naphthoquinones
ligand binding
docking analysis
Online Access:https://www.mdpi.com/1422-0067/21/11/4111

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https://www.mdpi.com/1422-0067/21/11/4111

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