Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted in 65% of subjects developing typhoid fever (referred here as typhoid diagnosis -TD-) 5-10 days post-challenge. TD criteria included meeting...

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Bibliographic Details
Main Authors: Franklin R Toapanta, Paula J Bernal, Stephanie Fresnay, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4465829?pdf=render

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http://europepmc.org/articles/PMC4465829?pdf=render

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