Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Scaffold

Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Scaffold

c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated in important pathological processes, including rheumatoid arthritis and ischemia-reperfusion injury. Therefore, inhibition of JNK is of interest for molecular targeted therapy to treat various diseases. We syn...

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Bibliographic Details
Main Authors: Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna I. Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Irina Y. Bagryanskaya, Mark T. Quinn
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
c-Jun N-terminal kinase
kinase inhibitor
11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one
oxime
interleukin-6
nuclear factor-κB
Online Access:https://www.mdpi.com/1420-3049/26/18/5688

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https://www.mdpi.com/1420-3049/26/18/5688

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