RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.

RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.

Advanced glycation end-products (AGEs) have been implicated in diverse pathological settings including diabetes, inflammation and acute ischemia/reperfusion injury in the heart. AGEs interact with the receptor for AGEs (RAGE) and transduce signals through activation of MAPKs and proapoptotic pathway...

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Bibliographic Details
Main Authors: Linshan Shang, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Mariane Abdillahi, Zhengbin Zhu, Wu Qu, Rosa Rosario, Fatouma Touré, Shi Fang Yan, Ann Marie Schmidt, Ravichandran Ramasamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2852407?pdf=render

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http://europepmc.org/articles/PMC2852407?pdf=render

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