Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants.

Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants.

D222G/N substitutions in A(H1N1)pdm09 hemagglutinin may be associated with increased binding of viruses causing low respiratory tract infections and human pathogenesis. We assessed the impact of such substitutions on the balance between hemagglutinin binding and neuraminidase cleavage, viral growth...

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Bibliographic Details
Main Authors: Jean-Sébastien Casalegno, Olivier Ferraris, Vanessa Escuret, Maude Bouscambert, Corinne Bergeron, Laetitia Linès, Thierry Excoffier, Martine Valette, Emilie Frobert, Sylvie Pillet, Bruno Pozzetto, Bruno Lina, Michèle Ottmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25119465/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25119465/?tool=EBI

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