Tau <i>N</i>-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model

Tau <i>N</i>-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model

The microtubule-associated protein tau can undergo liquid–liquid phase separation (LLPS) to form membraneless condensates in neurons, yet the underlying molecular mechanisms and functions of tau LLPS and tau droplets remain to be elucidated. The human brain contains mainly 6 tau isoforms with differ...

Full description

Bibliographic Details
Main Authors: Chengchen Wu, Junyi Zhao, Qiuping Wu, Qiulong Tan, Qiong Liu, Shifeng Xiao
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
liquid–liquid phase separation
tau isoforms
protein aggregation
p62 protein
Online Access:https://www.mdpi.com/1422-0067/22/18/9728

Internet

https://www.mdpi.com/1422-0067/22/18/9728

Similar Items