Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The glycolytic enzyme Pyruvate Kinase Muscle 2 (PKM2) has described roles in regulat...

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Bibliographic Details
Main Authors: Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, Daniel W McVicar, David K Finlay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
metabolism
immunology
nk cells
Online Access:https://elifesciences.org/articles/59166

Internet

https://elifesciences.org/articles/59166

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