DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells

DNA repair: tying up loose ends Carefully regulated enzymatic processing of the ends of DNA strands is essential for efficient replication and damage repair while also minimizing the risk of genomic instability. Replication and repair depend on a mechanism known as DNA resection, in which enzymes tr...

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Bibliographic Details
Main Authors: Fei Zhao, Wootae Kim, Jake A. Kloeber, Zhenkun Lou
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-00519-1