The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1

The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1

Calmodulin (CaM) is well known as an activator of calcium/calmodulin-dependent protein kinase II (CaMKII). Voltage-gated sodium channels (VGSCs) are basic signaling molecules in excitable cells and are crucial molecular targets for nervous system agents. However, the way in which Ca2+/CaM/CaMKII cas...

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Bibliographic Details
Main Authors: Jianing Li, Zhiyi Yu, Jianjun Xu, Rui Feng, Qinghua Gao, Tomasz Boczek, Junyan Liu, Zhi Li, Qianhui Wang, Ming Lei, Jian Gong, Huiyuan Hu, Etsuko Minobe, Hong-Long Ji, Masaki Kameyama, Feng Guo
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
Ca2+
CaM
CaMKII
NaV1.1
IQ domain
Online Access:http://www.mdpi.com/1422-0067/19/9/2495

Internet

http://www.mdpi.com/1422-0067/19/9/2495

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