Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1

Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1

We have recently found that diabetes-induced premature senescence of retinal endothelial cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase enzyme arginase 1 (A1). Here, we used genetic strategies to determine the specific involvement of A1 in diabetes-induced endothel...

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Bibliographic Details
Main Authors: Esraa Shosha, Zhimin Xu, S. Priya Narayanan, Tahira Lemtalsi, Abdelrahman Y. Fouda, Modesto Rojas, Ji Xing, David Fulton, R. William Caldwell, Ruth B. Caldwell
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
senescence
diabetes mellitus
diabetic retinopathy
arginase
retina
endothelial cells
hyperglycemia
Online Access:http://www.mdpi.com/1422-0067/19/4/1215

Internet

http://www.mdpi.com/1422-0067/19/4/1215

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