GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy

GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy

Abstract Background Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose-dependent insulin secretion and intestinal glucagon-like peptide-1 production. However, the function of GPR119 in cancer cells has not been studied. Methods GPR119 expressi...

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Bibliographic Details
Main Authors: Ji Hye Im, Keon Wook Kang, Sun Young Kim, Yoon Gyoon Kim, Yong Jin An, Sunghyouk Park, Byung Hwa Jeong, Song-Yi Choi, Jin-Sun Lee
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autophagy
Breast cancer
Gefitinib
GPR119 agonist
Lactate
Online Access:http://link.springer.com/article/10.1186/s13046-018-0949-2

Internet

http://link.springer.com/article/10.1186/s13046-018-0949-2

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