Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to th...

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Bibliographic Details
Main Authors: Sherine N. Khattab, Hosam H. Khalil, Adnan A. Bekhit, Mohamed Mokbel Abd El-Rahman, Ayman El-Faham, Fernando Albericio
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
1,3,5-triazine derivatives
amino acids
morpholine
piperidine
monoamine oxidase
Online Access:http://www.mdpi.com/1420-3049/20/9/15976

Internet

http://www.mdpi.com/1420-3049/20/9/15976

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