Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

Abstract Purpose The PET radioligand (R)-[11C]PK11195 is used to quantify the 18-kDa translocator protein (TSPO), a marker for glial activation. Since there is no brain region devoid of TSPO, an arterial input function (AIF) is ideally required for quantification of binding. However, obtaining an AI...

Full description

Bibliographic Details
Main Authors: Pontus Plavén-Sigray, Granville James Matheson, Zsolt Cselényi, Aurelija Jucaite, Lars Farde, Simon Cervenka
Format: Article
Language:English
Published: SpringerOpen 2018-11-01
Series:EJNMMI Research
Subjects:
(R)-[11C]PK11195
Arterial input function
Reference region
Supervised cluster analysis
Test-retest
Reliability
Online Access:http://link.springer.com/article/10.1186/s13550-018-0455-8

Internet

http://link.springer.com/article/10.1186/s13550-018-0455-8

Similar Items