Functional Roles of Bromodomain Proteins in Cancer

Functional Roles of Bromodomain Proteins in Cancer

Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the development of cancer. Bromodomains represent...

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Bibliographic Details
Main Authors: Samuel P. Boyson, Cong Gao, Kathleen Quinn, Joseph Boyd, Hana Paculova, Seth Frietze, Karen C. Glass
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
cancer
bromodomain
epigenetic gene regulation
histone post-translational modifications
chromatin reader
protein-protein interaction network
Online Access:https://www.mdpi.com/2072-6694/13/14/3606

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https://www.mdpi.com/2072-6694/13/14/3606

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