Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

Metabolic disorders such as type 2 diabetes cause hepatic endoplasmic reticulum (ER) stress, which affects neutral lipid metabolism. However, the role of ER stress in cholesterol metabolism is incompletely understood. Here, we show that induction of acute ER stress in human hepatic HepG2 cells reduc...

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Bibliographic Details
Main Authors: Clemens Röhrl, Karin Eigner, Katharina Winter, Melanie Korbelius, Sascha Obrowsky, Dagmar Kratky, Werner J. Kovacs, Herbert Stangl
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Lipid Research
Subjects:
ATP-binding cassette transporter A1
apolipoprotein A-I
high density lipoprotein
3-hydroxy-3-methylglutaryl- coenzyme A reductase
HepG2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317454

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http://www.sciencedirect.com/science/article/pii/S0022227520317454

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