Synthesis of Novel N-(4-Ethoxyphenyl) Azetidin-2-ones and Their Oxidative N-Deprotection by Ceric Ammonium Nitrate

Synthesis of Novel N-(4-Ethoxyphenyl) Azetidin-2-ones and Their Oxidative N-Deprotection by Ceric Ammonium Nitrate

It is shown that the N-(p-ethoxyphenyl) group on β-lactams can be oxidatively removed by ceric ammonium nitrate in good yield. Fourteen new N-(p-ethoxyphenyl)-2-azetidinones 8a-n were synthesized through standard [2+2] ketene-imine cycloadditions (Staudinger reaction). Treatment of these compound...

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Bibliographic Details
Main Authors: Maaroof Zarei, Aliasghar Jarrahpour
Format: Article
Language:English
Published: MDPI AG 2007-10-01
Series:Molecules
Subjects:
-Azetidinones
N-insubstituted β-Lactam
ceric ammonium nitrate
2-Azetidinones
Staudinger reaction
p-ethoxyphenyl (PEP) group
Online Access:http://www.mdpi.com/1420-3049/12/10/2364/

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http://www.mdpi.com/1420-3049/12/10/2364/

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