Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis

Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis

Endometriosis (EM) is characterized by the growth of endometrium-like tissue outside the uterus, leading to chronic inflammation and pelvic pain. Lesion proliferation, vascularization, and associated inflammation are the hallmark features of EM lesions. The legalization of recreational cannabinoids...

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Bibliographic Details
Main Authors: Harshavardhan Lingegowda, Jessica E. Miller, Ryan M. Marks, Lindsey K. Symons, Taylor Alward, Alan E. Lomax, Madhuri Koti, Chandrakant Tayade
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Reproductive Health
Subjects:
cannabinoids
endometriosis
apoptosis
inflammation
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/frph.2021.726936/full

Internet

https://www.frontiersin.org/articles/10.3389/frph.2021.726936/full

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