Right Dose, Right Now: Development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients

Right Dose, Right Now: Development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients

IntroductionAntibiotic dosing in critically ill patients is challenging because their pharmacokinetics (PK) are altered and may change rapidly with disease progression. Standard dosing frequently leads to inadequate PK exposure. Therapeutic drug monitoring (TDM) offers a potential solution but requi...

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Bibliographic Details
Main Authors: Luca F. Roggeveen, Tingjie Guo, Ronald H. Driessen, Lucas M. Fleuren, Patrick Thoral, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul Elbers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
clinical decision support
precision medicine
antibiotic dosing
sepsis
TDM (therapeutic drug monitoring)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00646/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00646/full

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