Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways

Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways

Background and Objective: Diabetes mellitus (DM) is reportedly a significant risk factor for intervertebral disc degeneration (IDD). Incretin system and particularly glucagon-like peptide 1 (GLP-1) because of its glucose-lowering effects has become an important target in therapeutic strategies of ty...

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Bibliographic Details
Main Authors: Mingyan Yao, Jing Zhang, Zhihong Li, Xiaoliang Bai, Jinhui Ma, Yukun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
apoptosis
liraglutide
nucleus pulposus cells
signaling pathway
diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.630962/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.630962/full

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