Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While LAMP-2A works as a receptor for protein substrates at the lysosomal membrane,...

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Bibliographic Details
Main Authors: Iván E. Alfaro, Amelina Albornoz, Alfredo Molina, José Moreno, Karina Cordero, Alfredo Criollo, Mauricio Budini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Endocrinology
Subjects:
CMA
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00778/full