XIAP antagonist embelin inhibited proliferation of cholangiocarcinoma cells.

XIAP antagonist embelin inhibited proliferation of cholangiocarcinoma cells.

Cholangiocarcinoma cells are dependent on antiapoptotic signaling for survival and resistance to death stimuli. Recent mechanistic studies have revealed that increased cellular expression of the E3 ubiquitin-protein ligase X-linked inhibitor of apoptosis (XIAP) impairs TRAIL- and chemotherapy-induce...

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Bibliographic Details
Main Authors: Cody J Wehrkamp, Ashley R Gutwein, Sathish Kumar Natarajan, Mary Anne Phillippi, Justin L Mott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3946004?pdf=render

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http://europepmc.org/articles/PMC3946004?pdf=render

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