Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus of shark TcR. SHM in developing shark T cells likel...

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Bibliographic Details
Main Authors: Jeannine A Ott, Caitlin D Castro, Thaddeus C Deiss, Yuko Ohta, Martin F Flajnik, Michael F Criscitiello
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
somatic hypermutation
T cell receptor
shark
evolution
AID
thymus
Online Access:https://elifesciences.org/articles/28477

Internet

https://elifesciences.org/articles/28477

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