Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship

Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship

Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of symptoms are suboptimal. Clinical suspicion therefore frequently leads to empirical antibiotic therapy in uninfected infa...

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Bibliographic Details
Main Authors: Claus Klingenberg, René F. Kornelisse, Giuseppe Buonocore, Rolf F. Maier, Martin Stocker
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pediatrics
Subjects:
neonate
sepsis
blood culture
C-reactive protein
procalcitonin
Online Access:https://www.frontiersin.org/article/10.3389/fped.2018.00285/full

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https://www.frontiersin.org/article/10.3389/fped.2018.00285/full

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