Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

Recent studies indicate that the Parkinson's disease-linked leucine-rich repeat kinase 2 (LRRK2) modulates cytoskeletal functions by regulating actin and tubulin dynamics, thereby affecting neurite outgrowth. By interactome analysis we demonstrate that the binding of LRRK2 to tubulins is signif...

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Bibliographic Details
Main Authors: Mareike Caesar, Susanne Zach, Coby B. Carlson, Kathrin Brockmann, Thomas Gasser, Frank Gillardon
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Tubulin
Fibroblasts
Migration
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000107

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000107

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