Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury

Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+ channels, Ca2+ permeable...

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Bibliographic Details
Main Authors: Ryan L. O’Hare Doig, Sreya Santhakumar, Brooke Fehily, Sushmitha Raja, Tanya Solomon, Carole A. Bartlett, Melinda Fitzgerald, Stuart I. Hodgetts
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord injury
secondary degeneration
ion channel inhibitors
glia
calcium (Ca2+)
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00085/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00085/full

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