RNA virus interference via CRISPR/Cas13a system in plants

RNA virus interference via CRISPR/Cas13a system in plants

Abstract Background CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA) molecules of the phage genome. Here, we...

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Bibliographic Details
Main Authors: Rashid Aman, Zahir Ali, Haroon Butt, Ahmed Mahas, Fatimah Aljedaani, Muhammad Zuhaib Khan, Shouwei Ding, Magdy Mahfouz
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genome Biology
Subjects:
CRISPR/Cas systems
CRISPR/Cas13a
Virus interference
RNA interference
Molecular immunity
RNA knockdown
Online Access:http://link.springer.com/article/10.1186/s13059-017-1381-1

Internet

http://link.springer.com/article/10.1186/s13059-017-1381-1

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