DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies...

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Bibliographic Details
Main Authors: Fabrizio Gentile, Alessia Arcaro, Stefania Pizzimenti, Martina Daga, Giovanni Paolo Cetrangolo, Chiara Dianzani, Alessio Lepore, Maria Graf, Paul R. J. Ames, Giuseppina Barrera
Format: Article
Language:English
Published: AIMS Press 2017-04-01
Series:AIMS Genetics
Subjects:
lipid peroxidation
aldehydes
DNA adducts
cancer
inflammation
autoimmunity
Online Access:http://www.aimspress.com/Genetics/article/1385/fulltext.html

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http://www.aimspress.com/Genetics/article/1385/fulltext.html

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