Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats
In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol vale...
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Academia Brasileira de Neurologia (ABNEURO)
2013-05-01
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doaj-14dd153daed34401a2bc915490b90f0e2020-11-25T00:33:28ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272013-05-0171531331910.1590/0004-282X20130027S0004-282X2013000500313Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized ratsFatimeh KhodabandehlooMahmoud HosseiniZiba RajaeiMohammad SoukhtanlooEsmaeil FarrokhiMohsen RezaeipourIn addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p≪0.01 and p≪0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q1 compared to Sham and OVX groups (p≪0.05 and p≪0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p≪0.05 and p≪0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000500313&lng=en&tlng=enaprendizadomemóriaovariectomiaestradiolLabirinto Aquático de Morrisestresse oxidativo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatimeh Khodabandehloo Mahmoud Hosseini Ziba Rajaei Mohammad Soukhtanloo Esmaeil Farrokhi Mohsen Rezaeipour |
spellingShingle |
Fatimeh Khodabandehloo Mahmoud Hosseini Ziba Rajaei Mohammad Soukhtanloo Esmaeil Farrokhi Mohsen Rezaeipour Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats Arquivos de Neuro-Psiquiatria aprendizado memória ovariectomia estradiol Labirinto Aquático de Morris estresse oxidativo |
author_facet |
Fatimeh Khodabandehloo Mahmoud Hosseini Ziba Rajaei Mohammad Soukhtanloo Esmaeil Farrokhi Mohsen Rezaeipour |
author_sort |
Fatimeh Khodabandehloo |
title |
Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
title_short |
Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
title_full |
Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
title_fullStr |
Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
title_full_unstemmed |
Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
title_sort |
brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats |
publisher |
Academia Brasileira de Neurologia (ABNEURO) |
series |
Arquivos de Neuro-Psiquiatria |
issn |
1678-4227 |
publishDate |
2013-05-01 |
description |
In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p≪0.01 and p≪0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q1 compared to Sham and OVX groups (p≪0.05 and p≪0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p≪0.05 and p≪0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress. |
topic |
aprendizado memória ovariectomia estradiol Labirinto Aquático de Morris estresse oxidativo |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000500313&lng=en&tlng=en |
work_keys_str_mv |
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