A systematic mutational analysis identifies a 5‐residue proline tag that enhances the in vivo immunogenicity of a non‐immunogenic model protein

A systematic mutational analysis identifies a 5‐residue proline tag that enhances the in vivo immunogenicity of a non‐immunogenic model protein

Poor immunogenicity of small proteins is a major hurdle in developing vaccines or producing antibodies for biopharmaceutical usage. Here, we systematically analyzed the effects of 10 solubility controlling peptide tags (SCP‐tags) on the immunogenicity of a non‐immunogenic model protein, bovine pancr...

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Bibliographic Details
Main Authors: Nafsoon Rahman, Mohammad Monirul Islam, Md. Golam Kibria, Satoru Unzai, Yutaka Kuroda
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:FEBS Open Bio
Subjects:
immunogenicity
monomer
peptide tag
protein solubility
SCP
Online Access:https://doi.org/10.1002/2211-5463.12941

Internet

https://doi.org/10.1002/2211-5463.12941

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