Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Friedreich ataxia is considered a neurodegenerative disorder involving both the peripheral and central nervous systems. Dorsal root ganglia (DRG) are the major target tissue structures. This neuropathy is caused by mutations in the FXN gene that encodes frataxin. Here, we investigated the mitochondr...

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Bibliographic Details
Main Authors: Arantxa eBolinches-Amorós, Belén eMollá, David ePla-Martín, Francesc ePalau, Pilar eGonzalez-Cabo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
Friedreich Ataxia
Mitochondrial dysfunction
ER-stress
cellular senescence
frataxin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00124/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00124/full

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