A mechanistic study on the destabilization of whole inactivated influenza virus vaccine in gastric environment.

Oral immunization using whole inactivated influenza virus vaccine promises an efficient vaccination strategy. While oral vaccination was hampered by harsh gastric environment, a systematic understanding about vaccine destabilization mechanisms was not performed. Here, we investigated the separate an...

Full description

Bibliographic Details
Main Authors: Hyo-Jick Choi, Charles F Ebersbacher, Min-Chul Kim, Sang-Moo Kang, Carlo D Montemagno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776657/pdf/?tool=EBI