m5C modification of mRNA serves a DNA damage code to promote homologous recombination

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

Bibliographic Details
Main Authors: Hao Chen, Haibo Yang, Xiaolan Zhu, Tribhuwan Yadav, Jian Ouyang, Samuel S. Truesdell, Jun Tan, Yumin Wang, Meihan Duan, Leizhen Wei, Lee Zou, Arthur S. Levine, Shobha Vasudevan, Li Lan
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16722-7

Internet

https://doi.org/10.1038/s41467-020-16722-7

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