m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

Bibliographic Details
Main Authors:	Hao Chen, Haibo Yang, Xiaolan Zhu, Tribhuwan Yadav, Jian Ouyang, Samuel S. Truesdell, Jun Tan, Yumin Wang, Meihan Duan, Leizhen Wei, Lee Zou, Arthur S. Levine, Shobha Vasudevan, Li Lan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16722-7

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spelling	doaj-14e92aba6993424088f192e1fc7c093c2021-06-06T11:15:10ZengNature Publishing GroupNature Communications2041-17232020-06-0111111210.1038/s41467-020-16722-7m5C modification of mRNA serves a DNA damage code to promote homologous recombinationHao Chen0Haibo Yang1Xiaolan Zhu2Tribhuwan Yadav3Jian Ouyang4Samuel S. Truesdell5Jun Tan6Yumin Wang7Meihan Duan8Leizhen Wei9Lee Zou10Arthur S. Levine11Shobha Vasudevan12Li Lan13Department of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Pathology, Massachusetts General Hospital, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicinePost-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.https://doi.org/10.1038/s41467-020-16722-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan
spellingShingle	Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan m5C modification of mRNA serves a DNA damage code to promote homologous recombination Nature Communications
author_facet	Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan
author_sort	Hao Chen
title	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_short	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_full	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_fullStr	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_full_unstemmed	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_sort	m5c modification of mrna serves a dna damage code to promote homologous recombination
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.
url	https://doi.org/10.1038/s41467-020-16722-7
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m5C modification of mRNA serves a DNA damage code to promote homologous recombination

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