Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis

Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis

Abstract Background Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSCs from ARAS patients exhibit impaired function, senescence, and DNA dam...

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Main Authors: Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, Stephen C. Textor, Lilach O. Lerman, Sandra M. Herrmann
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Hypoxia
Angiogenesis
Senescence
Epigenetics
Hydroxymethylation
Online Access:https://doi.org/10.1186/s13287-021-02310-z

Internet

https://doi.org/10.1186/s13287-021-02310-z

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