Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the <i>HTT</i> gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of the putamen followed by other br...

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Bibliographic Details
Main Authors: Stefano Patassini, Paul Begley, Jingshu Xu, Stephanie J. Church, Nina Kureishy, Suzanne J. Reid, Henry J. Waldvogel, Richard L. M. Faull, Russell G. Snell, Richard D. Unwin, Garth J. S. Cooper
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Metabolites
Subjects:
Huntington’s disease
neurodegeneration
vitamin B5
acetyl-coenzyme A
brain energy metabolism
acetylcholine biosynthesis
metabolomics
bioinformatics
data visualisation
data analytics
Online Access:https://www.mdpi.com/2218-1989/9/6/113

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https://www.mdpi.com/2218-1989/9/6/113

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