Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Abstract Background The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343...

Full description

Bibliographic Details
Main Authors: Francis Tsombeng Foguim, Hervé Bogreau, Mathieu Gendrot, Joel Mosnier, Isabelle Fonta, Nicolas Benoit, Rémy Amalvict, Marylin Madamet, Sharon Wein, Bruno Pradines, The French National Reference Centre for Imported Malaria Study Group
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Antimalarial drug
Resistance
In vitro
Molecular marker
Online Access:http://link.springer.com/article/10.1186/s12936-020-03281-x

Internet

http://link.springer.com/article/10.1186/s12936-020-03281-x

Similar Items