Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death

This work reports the biological evaluation of a copper complex of the type [Cu(O–O)(N–N)ClO4], in which O–O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N–N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect of CBP-01 was evaluated by resazurin assay and cell...

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Bibliographic Details
Main Authors: Lorena Polloni, Ana Carolina de Seni Silva, Samuel Cota Teixeira, Fernanda Van Petten de Vasconcelos Azevedo, Mariana Alves Pereira Zóia, Marcelo Santos da Silva, Paula Marynella Alves Pereira Lima, Lucas Ian Veloso Correia, Janaina do Couto Almeida, Claudio Vieira da Silva, Veridiana de Melo Rodrigues Ávila, Luiz Ricardo Filho Goulart, Sandra Morelli, Wendell Guerra, Robson José de Oliveira Júnior
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Copper complex
Cytotoxicity
Apoptosis
Cell cycle
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218370963

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http://www.sciencedirect.com/science/article/pii/S0753332218370963

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