Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice

Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice

Effort-related choice (ERC) tasks allow animals to choose between high-value reinforcers that require high effort to obtain and low-value/low-effort reinforcers. Dopaminergic neuromodulation regulates ERC behavior. The enzyme catechol-O-methyltransferase (COMT) metabolizes synaptically-released dopa...

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Bibliographic Details
Main Authors: Adrienne C. DeBrosse, Abigail M. Wheeler, James C. Barrow, Gregory V. Carr
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
dopamine
tolcapone
catechol-O-methyltransferase
motivation
touchscreen
prefrontal cortex
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2020.00073/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2020.00073/full

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