Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: A proof of concept study.

Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: A proof of concept study.

Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in non-survivor septic shock patients. The aim of this study was to evaluate the benefits of inhibiting cDPP3 by a speci...

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Bibliographic Details
Main Authors: Benjamin Deniau, Alice Blet, Karine Santos, Prabakar Vaittinada Ayar, Magali Genest, Mandy Kästorf, Malha Sadoune, Andreia de Sousa Jorge, Jane Lise Samuel, Nicolas Vodovar, Andreas Bergmann, Alexandre Mebazaa, Feriel Azibani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0238039

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https://doi.org/10.1371/journal.pone.0238039

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