A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy

A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy

Abstract To formulate a nanoformulation (PLGA-NPs) and to improve brain bioavailability for thymoquinone (THQ) through intranasal (i.n.) drug delivery, using a newly UHPLC-PDA developed the method and validated. Five different THQ-PLGA-NPs (THQ-N1 to THQ-N5) were prepared by emulsion solvent evapora...

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Bibliographic Details
Main Authors: Niyaz Ahmad, Rizwan Ahmad, Sadiq Al Qatifi, Mahdi Alessa, Hassan Al Hajji, Md Sarafroz
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Chemistry
Subjects:
Thymoquinone
PLGA-nanoparticles
Epilepsy
UHPLC-PDA
Brain bioavailability and pharmacokinetic
Online Access:https://doi.org/10.1186/s13065-020-0664-x

Internet

https://doi.org/10.1186/s13065-020-0664-x

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