Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase.

As an important part of metabolism, metabolic flux through the glycolytic pathway is tightly regulated. The most complex control is exerted on 6-phosphofructo-1-kinase (PFK1) level; this control overrules the regulatory role of other allosteric enzymes. Among other effectors, citrate has been report...

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Bibliographic Details
Main Authors: Aleksandra Usenik, Matic Legiša
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21124851/?tool=EBI