Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00500-z |
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doaj-15032712babd4934b8cf9987f86cc0ba2021-05-11T07:47:29ZengNature Publishing GroupNature Communications2041-17232017-09-018111510.1038/s41467-017-00500-zHepcidin is regulated by promoter-associated histone acetylation and HDAC3Sant-Rayn Pasricha0Pei Jin Lim1Tiago L. Duarte2Carla Casu3Dorenda Oosterhuis4Katarzyna Mleczko-Sanecka5Maria Suciu6Ana Rita Da Silva7Kinda Al-Hourani8João Arezes9Kirsty McHugh10Sarah Gooding11Joe N. Frost12Katherine Wray13Ana Santos14Graça Porto15Emmanouela Repapi16Nicki Gray17Simon J. Draper18Neil Ashley19Elizabeth Soilleux20Peter Olinga21Martina U. Muckenthaler22Jim R. Hughes23Stefano Rivella24Thomas A. Milne25Andrew E. Armitage26Hal Drakesmith27MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordInstituto de Investigação e Inovação em Saúde and IBMC—Instituto de Biologia Molecular e Celular, University of PortoDivision of Hematology, Department of Pediatrics, Children’s Hospital of PhiladelphiaPharmaceutical Technology and Biopharmacy, Department of Pharmacy, University of GroningenDepartment of Pediatric Hematology, Oncology and Immunology, University of Heidelberg; and Molecular Medicine Partnership UnitMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordDepartment of Pediatric Hematology, Oncology and Immunology, University of Heidelberg; and Molecular Medicine Partnership UnitMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordJenner Institute, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordInstituto de Investigação e Inovação em Saúde and IBMC—Instituto de Biologia Molecular e Celular, University of PortoInstituto de Investigação e Inovação em Saúde and IBMC—Instituto de Biologia Molecular e Celular, University of PortoComputational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe HospitalComputational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe HospitalJenner Institute, University of OxfordMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford UniversityPharmaceutical Technology and Biopharmacy, Department of Pharmacy, University of GroningenDepartment of Pediatric Hematology, Oncology and Immunology, University of Heidelberg; and Molecular Medicine Partnership UnitMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordDivision of Hematology, Department of Pediatrics, Children’s Hospital of PhiladelphiaMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordHepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.https://doi.org/10.1038/s41467-017-00500-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith |
| spellingShingle |
Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 Nature Communications |
| author_facet |
Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith |
| author_sort |
Sant-Rayn Pasricha |
| title |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 |
| title_short |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 |
| title_full |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 |
| title_fullStr |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 |
| title_full_unstemmed |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 |
| title_sort |
hepcidin is regulated by promoter-associated histone acetylation and hdac3 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-09-01 |
| description |
Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency. |
| url |
https://doi.org/10.1038/s41467-017-00500-z |
| work_keys_str_mv |
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