P-glycoprotein polymorphism and levothyroxine bioavailability in hypothyroid patients

Objectives: P-glycoprotein (P-gp) contributes to the disposition of a wide variety of drugs; therefore, single nucleotide polymorphisms (SNPs) in the P-gp coding gene might affect its activity. It is well known that personalized medicine, instead of empirical treatment, is a clinically important app...

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Bibliographic Details
Main Authors: Ezgi Öztaş, Alejandro Parejo Garcia-Saavedra, Fatih Yanar, Beyza Özçinar, Nihat Aksakal, Sevim Purisa, Gül Özhan
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Saudi Pharmaceutical Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016417302074